Resveratrol to help Diabetes and Obesity??
Another study…in a long line of them demonstrates the benefits from this incredible nutrient. This time it is an animal one which has shown this nutrient to be beneficial in helping avoid Diabetes and Obesity.
But…don’t rush out and buy Reservatrol just on the strength of this. It is only one of many nutrients that are needed for optimal health. Also, you don’t need to as we have a generous dose of it in our Total Balance. In fact, we were one of the first supplement companies to start using it years ago…. The 32mgs a day we use in Total Balance is the equivalent of what you would get in several bottles of red wine.
I will write in more detail about reservatrol later when my current work pressure eases a bit. I will tell you how Reservatrol has also been found to mimic calorie restriction which in turn leads to increased longevity…without having to starve yourself. Its pretty exciting stuff.
For the moment if you would like to know more about this latest study just click here to read an article about it.
By the way, the reservatrol in Total Balance is as good as it gets for bio-availability due to the enteric coated delivery system we use.
Warren Matthews
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After ensuring that the ingredient conforms which the specifications (which we do for each batch) then the key from that point on is the way it is handled and incorporated into the final product.
The product you referred to is not protected from stomach acid by enteric coating. Also, no mention is made of the potency of the resveratrol. Is it 5% or 50%. We use 50%.
Further there is no evidence to suggest that more is better. The key is balance. 32mgs which we use is considered to be an ideal dose...maybe up to 50mgs. Anything more than this has not been proven to be beneficial or indeed safe over the long term and I certainly would not go for the high dose.
The site that you referred to is a good selling site. I see though that they have removed their reference to saying it was produced in an FDA approved facilty when it was not. They had their knuckle rapped over that one and it has now been modified to say they follow FDA procedures.
Interestingly the price is similar to a bottle of Total Balance but you get a lot less for the same money.
So, in summary I would not agree that they have the best supplements...sorry.
Resveratrol Supplements can help you control your weight naturally
by increasing energy, reducing cravings, and limiting your appetite.
According to Wikipedia, Consumer Lab, an independent dietary
supplement and over the counter products evaluation organization,
published a report on 13 November 2007 on the popular resveratrol
supplements. The organization reported that there exists a wide range
in quality, dose, and price among the 13 resveratrol products
evaluated. The actual amount of resveratrol contained in the
different brands range from 2.2mg for Revatrol, which claimed to have
400mg of "Red Wine Grape Complex", to 500mg for Biotivia.com Transmax,
which is consistent with the amount claimed on the product's label.
Prices per 100mg of resveratrol ranged from less than $.30 for
products made by Biotivia.com, jarrow, and country life, to a high of
$45.27 for the Revatrol brand. None of the products tested were found
to have significant levels of heavy metals or other contaminants.
Just a small correction. ConsumerLab is not independent organization by a long shot. They play both sides of the fence. They select products to test, issue negative press releases saying that only so many products passed the test and to find out which one you have to buy a subscription.
On the other hand they canvass companies to submit their products for their seal of approval for a fee. If they pass they publish the results if they don't then you never hear anythng about it. If the fee is not paid then the results will be published.
I have written about them a couple of times in this blog.
http://blog.xtend-life.com/warren_matthews_blog/2007/3/30/consumer-lab-and-testing-of-supplements.html
and
http://blog.xtend-life.com/warren_matthews_blog/2008/2/14/consumerlab-finds-lead-in-tumeric-supplements.html
Your post brought up a couple of interesting valid points. For example, the 2.2mgs of reservatrol in 400mgs of Red wine grape complex is not surprising. A 'complex' is not reservatrol. The producers of this product are being deceptive if they were passing off the 'complex' as reservatrol. What you need to look for on the label is the type of reservatrol (it should be trans which is the natural form) and the percentage of active present. For example, in our case we use the 50% version at 32mgs so the net reservatrol is 16mgs.
Some companies use a 5% version. We are reviewing the potency for our next generation of Total Balance. The evidence at the time we determined the current level was based on current studies and was considered optimum. We may be making a small increase in the next generation to be released in July.
We certainly will not be using 500mgs as there is nothing to support this high a dose and what the long term effects are. More is definitely not always better.
http://www.ajc.com/services/content/health/stories/2008/06/03/anti_aging_drugs.html?cxtype=ybuzz?referrer=search_buy
Quoting from wikipedia
"
About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, oral bioavailability of resveratrol is low because it is rapidly metabolized in intestines and liver into conjugated forms: glucuronate and sulfonate.[27] Only trace amounts (below 5 ng/mL) of unchanged resveratrol could be detected in the blood after 25 mg oral dose.[27] Even when a very large dose of resveratrol (2.5 and 5 g) was given as an uncoated pill, the concentration of resveratrol in blood failed to reach the level necessary for the systemic cancer prevention.[28] However, resveratrol given in a proprietary formulation SRT-501 (3 or 5 g), developed by Sirtris Pharmaceuticals, reached 5–8 times higher blood levels. These levels did approach the concentration necessary to exert the effects shown in animal models and in vitro experiments.[2]
In humans[27][28] and rats,[29][30][31] less than 5% of the oral dose is being observed as free resveratrol in blood plasma. "
The references are their in the wikipedia article about resveratrol.
Also it is recomended that the buccal delivery is best for greater bio-availibility.
Not sure who wrote the article but there is one key point in it...and that is the reference to uncoated pills.
Resveratrol is very sensitive and the way it is incorporated into a tablet is very important. To maximize its bio-availability it should be enteric coated. That is probably what Sirtris does...and it is what we also do.
It is also important to keep in mind that there are many different forms of resveratrol. Some is natural, some is synthetic, some are potent, some are weak. For example, many manufacturers use 5% potency. We use 50% and only the natural form. When combined with the delivery system we use the best possible results can be expected.
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